The N–N bond is present in many important organic compounds, such as hydrazines, pyrazoles, azos, etc. Many methods based on transition metal catalyzed N–N coupling or functionalization of hydrazine have been reported for the synthesis of N–N containing organic compounds. In recent years, electrochemical dehydrogenative N–H/N–H coupling has become a powerful tool for the construction of N–N bearing organic compounds. The electrochemical methods employ electrons as traceless redox reagents instead of chemicals and produce hydrogen as the only byproduct. In this review, we summarize the recent advances in the electrochemical dehydrogenative N–H/N–H coupling reactions with focus on the mechanistic insights and synthetic applications of these transformations. 相似文献
We consider an affine process which is only observed up to an additive white noise, and we ask for the law of , for some , conditional on all observations up to time . This is a general, possibly high dimensional filtering problem which is not even locally approximately Gaussian, whence essentially only particle filtering methods remain as solution techniques. In this work we present an efficient numerical solution by introducing an approximate filter for which conditional characteristic functions can be calculated by solving a system of generalized Riccati differential equations depending on the observation and the process characteristics of . The quality of the approximation can be controlled by easily observable quantities in terms of a macro location of the signal in state space. Asymptotic techniques as well as maximization techniques can be directly applied to the solutions of the Riccati equations leading to novel very tractable filtering formulas. The efficiency of the method is illustrated with numerical experiments for Cox–Ingersoll–Ross and Wishart processes, for which Gaussian approximations usually fail. 相似文献
This paper is dedicated to studying the following Schrödinger–Poisson system Under some different assumptions on functions V(x), K(x), a(x) and f(u), by using the variational approach, we establish the existence of positive ground state solutions. 相似文献
The vapor–liquid phase equilibrium (VLE) data for binary systems of neohexane?+?cyclopentane, neohexane?+?N,N-dimethylformamide (DMF), cyclopentane?+?DMF and ternary system of neohexane?+?cyclopentane?+?DMF were determined with a modified Rose still at 101.3 kPa, and all the binary data passed the Wisniak’s test (D?<?5), which accorded with the thermodynamic consistency. Three activity coefficient models namely, Wilson, NRTL and UNIQUAC were used to correlate VLE data and get binary interaction parameters, then the ternary VLE data of neohexane?+?cyclopentane?+?DMF were estimated based on these model parameters using Aspen Plus software. The estimation values of the three models agree well with the experimental data (σ(T)?<?0.5 K). Moreover, the analysis of the effect of DMF on the vapor–liquid phase equilibrium shows that DMF can act as an effective extractant for the system studied.
The Casimir element of a fusion ring (R, B) gives rise to the so called Casimir matrix C of (R, B). This enables us to construct a generalized Cartan matrix D-C in the sense of Kac for a suitable diagonal matrix D. In this paper, we study some elementary properties of the Casimir matrix C and use them to realize certain fusion rings from the generalized Cartan matrix D-C of finite (resp. affine) type. It turns out that there exists a fusion ring with D-C being of finite (resp. affine) type if and only if D-C has only the form A2 (resp. A1(1). We also realize all fusion rings with D-C being a particular generalized Cartan matrix of indefinite type. 相似文献
Photodynamic therapy (PDT) agents may accumulate in skin and cause severe skin cytotoxicity. We report a pro-guest-based supramolecular strategy to selectively activate PDT in the reactive oxygen specie (ROS) overexpressed microenvironment, which is often existing in tumor and inflammatory tissues. PDT agents methylene blue (MB) and basic blue 17 (BB17) are used as model drugs. When encapsulated by acyclic cucurbit[n]uril (CB[n]), the efficacy of PDT agents is significantly inhibited. By contrast, in the presence of ROS (H2O2) and pro-guest, PDT agents are displaced and reactivated to show a dramatically enhanced PDT efficacy in cells. 相似文献
Visible-light-mediated para-C–H difluoroalkylation of anilides via combination of steric effects and Lewis acid activation strategies has been developed. The addition of (C6H5O)2P(O)OH and Ag2CO3 properly tune the redox potential of ruthenium catalyst and leads to mild reaction conditions. The protocol exhibits broad functional group tolerance and allows the late-stage functionalization of complex bioactive molecules. 相似文献
A facile and elegant method for synthesis of novel N–aryl phenothiazine derivatives from 2-phenylindolizines and phenothiazines through direct electrochemical oxidation has been developed. This approach was performed smoothly at room temperature without external oxidant and catalyst. Cyclic voltammetry and in situ FTIR techniques were applied to analyze the cross-coupling process of phenothiazines and 2-phenylindolizines, which helped to select the appropriate reaction potential. Under the optimized conditions, a broad range of substrates were well tolerated, affording the desired products in moderate to excellent isolated yields (up to 91%) with high regioselectivity. Meanwhile, a plausible mechanism involving a radical pathway has been proposed. 相似文献
In the present study, high-performance liquid chromatography micro-fraction bioactive evaluation and high speed countercurrent chromatography were performed on screening, identification and isolation of antioxidants from Citrus peel. Three compounds were screened as antioxidants and tyrosinase inhibitors using 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation scavenging assay and tyrosinase activity test, then they were identified as eriocitrin, narirutin and hesperidin. Moreover, the solvent system ethyl acetate-n-butanol-water (6:4:10, v/v/v) was used for separation of ethyl acetate extract of Citrus peel by high speed countercurrent chromatography. In total, 0.45 mg of eriocitrin with 87.10% purity, 2.04 mg of narirutin with 95.19% purity and 1.35 mg of hesperidin with 95.19% purity were obtained from 20 mg of ethyl acetate extract of Citrus peel in a single run and then each component was subjected to 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation scavenging assay and tyrosinase inhibition assay. Eriocitrin showed great antioxidant activity (the half-maximum concentration: 3.65 µM) and tyrosinase inhibition activity (the half-maximum concentration: 115.67 µM), while narirutin and hesperidin exhibited moderate activity. Tyrosinase inhibition activity for eriocitrin in vitro was reported for the first time. Furthermore, molecular docking between eriocitrin and mushroom tyrosinase was also studied. 相似文献